Backup Failing v-79-57344-65003 and 0xe00084af

Hello,

I inherited a backup duty and I need help stabilizing the backup.

It ran fine for two days and then started choking,

Backup Exec 2010 R3 Version 13.0 Rev. 5204

Windows Server 2003 R2  it is the domain controller

Here is the error:

Job ended: Friday, April 11, 2014 at 4:07:29 AM
Completed status: Failed
Final error: 0xe00084af - The directory or file was not found, or could not be accessed.
Final error category: Job Errors

For additional information regarding this error refer to link V-79-57344-33967

The backup hits the USERS\Name directory and just begins to choke on alot that comes after. For the last two days it has hit the USERS directory and when it chokes on one user it appears to chooke on every user thereafter. It was not th same user each time.

V-79-57344-65033 - Directory not found. Cannot backup directory \Data\Users\USERNAME\PLP and its subdirectories. etc

V-79-57344-65033 - Directory not found. Cannot backup directory \System Volume Information and its subdirectories.

V-79-57344-65033 - Directory not found. Cannot backup directory \WINNT and its subdirectories.

These are all on the C:\ drive of the computer.

Other items backed up on different computers are Sharepoint and an SQL database.

Any help would be good.