Best Practices for ClearCase Backups?

When running ClearCase on a Hyper-V VM, what are some best-practice considerations when using Backup Exec 2012?

• What Symantec agent licenses are required for Hyper-V backups?
• Do agents need to be installed on the VM or just the host?
• What pre/post command scripts should be run?
• Are there special considerations when backing up vob repositories?
• Is file locking necessary when using snapshot technology?
• Does Backup Exec work well with IBM's Multisite for disaster recovery?

...and any other tips on either CleaseCase or Hyper-V backups.